Richard Alan McIndoe

Associate Professor
Associate Director, Center for Biotechnology               Phone: (706) 733-0188 x2392
and Genomic Medicine                                                    FAX:   (706) 823-2269
Medical College of Georgia                                             rmcindoe@mail.mcg.edu
Augusta, GA 30912

Experience 

7/02 – present    Associate Professor
                             Associate Director, Center for Biotechnology and Genomic Medicine
                             Medical College of Georgia, Augusta, GA

 11/99-6/02       Assistant Professor
                           Department of Pathology
                           University of Florida, Gainesville, FL

 3/99-10/99       Group Leader
                           Full Length Cloning Facility
                          CuraGen Corporation, Alachua, FL

 11/97-3/99      Senior Research Scientist
                          Full Length Cloning Facility
                          CuraGen Corporation, Alachua, FL

 10/98-11/99     Courtesy Assistant Professor
                           Biotechnology Program
                           University of Florida, Gainesville, FL

 1997-present  Board of Directors
                          The Institute for Science Training and Research, Inc.
                          Seattle, WA

1997                Research Associate
                         Department of Molecular Biotechnology
                         University of Washington, Seattle, WA

1996-1997     Vice President, Consulting Division
                        The Institute for Science Training and Research, Inc.
                        Seattle, WA.

1992-1997      Postdoctoral Fellow, (Leroy Hood, M.D., Ph.D.-Advisor)
                         Department of Molecular Biotechnology,
                         University of Washington , Seattle, WA

1991-1992      Postdoctoral Assistant; (Edward K. Wakeland Ph.D.-Advisor)
                         Department of Pathology and Laboratory Medicine,
                         University of Florida, Gainesville, FL

1984-1986     Laboratory Technician,
                        Department of Pathology and Laboratory Medicine,
                        University of Florida, Gainesville, FL 

Education: 

1984    B.S. in Microbiology and Cell Science;
             University of Florida, Gainesville, FL

 1991    Ph.D. in Immunology and Molecular Pathology;
              Edward K. Wakeland, Ph.D. –Advisor,
              Department of Pathology and Laboratory Medicine, 
               University of Florida, Gainesville, FL

 Computer Experience:

Professional History

Medical College of Georgia

Augusta, GA
Associate Professor            2002 – present
Associate Director, Center for Biotechnology and Genomic Medicine

Research interests include bioinformatics, automation, autoimmunity, and diabetes.  The research efforts focus on building the computing infrastructure for management of microarray data and looking at the temporal gene expression changes during the etiology of diabetes in rodent and human populations.

University of Florida
Gainesville, FL

Assistant Professor            1999 - 2002

Research interests include bioinformatics, automation, autoimmunity, and diabetes.  The research efforts focus on building the computing infrastructure for management of microarray data and looking at the temporal gene expression changes during the etiology of diabetes in rodent and human populations.

Molecular Staging, Inc.

66 High Street
Guilford, CT

Consultant – Polymorphism Detection Group  1999

Principle responsibility was to design and implement the high throughput  polymorphism detection facility of the Positional Cloning group.  Building the infrastructure for this process included hiring responsibilities, workflow design, automation design, SOP development, design of the database schema, writing web based data management/workflow code and order the reagents and equipment.

CuraGen Corporation

12085 Research Drive
Alachua, FL 32615

Group Leader - Full Length Cloning Facility            1997-1999

Responsibilities and achievements include the design and implementation of a high throughput Full Length Cloning facility.  The development of the infrastructure for this process included software and hardware solutions as well as the ability to build a team of qualified individuals.

Highlights: 

¨      Design and implementation of a high throughput Full Length Cloning facility

¨      Develop software solutions for the facility in conjunction with in-house bioinformatics team.

¨      Design and optimize process workflow to increase efficiency of full length cloning process.

¨      Build a team of scientists and technicians to produce weekly goals.

¨      Managed a team of five Ph.D. level scientists and 14 Research Associates

¨      Responsible for yearly operations plan, budgets, costing analysis and bi-weekly project allocations.

University of Washington

Leroy Hood, M.D. , Ph.D.
Seattle, WA

Postdoctoral fellow/Research Associate            1992-1997

Research efforts at the University of Washington had primarily focused on the development and implementation of a high throughput genotyping facility as well as mapping susceptibility loci for complex common diseases.  A critical evaluation of data flow for a genotyping facility lead to both hardware and software solutions in the areas of sample cataloging and disbursement, gel documentation and archiving, and genotype data capture.  The goal of this work was to develop seamless integration between the sample cataloging, sample preparation, genotype data collection and genotype data capture.  To this end, a number of databases with suitable front end forms were written to track sample movement as well as genotyping software to fully automate the data capture.  Currently, a number of  laboratories in the US and Canada are using our software and it is commercially available through an exclusive license to the LiCor Corporation.  I also advised other laboratories/companies concerning the day to day operation of a genotyping facility. 

My laboratory had four genetic mapping projects under way.  The first mapping project involved linkage analysis of high risk families for prostate cancer.  This project was part of the CapCURE prostate cancer consortium and was in collaboration with Elaine Ostrander at the Fred Hutchinson Cancer Research Center.  The second project involved linkage analysis of high risk families with Rheumatoid arthritis in a local Native American tribe (Yakima Indians).  We were in the family collection phase of this project when I left the University of Washington. The third project involved mapping susceptibility loci in a Rheumatoid arthritis-like mouse animal model called Collagen Induced Arthritis.  The final project was the same as the previous one with the exception of using a different strain of mouse, B10.RIII.  We had reason to suspect this strain will have unique loci involved in the disease and want to test for disease stratification.

University of Florida

Edward K. Wakeland, Ph.D.
Gainesville, FL

Ph.D. Candidate            1987-1991

Previous interests involved immunogenetics and the mouse major histocompatibility complex (Mhc).  In particular, I was interested in the origin of Mhc class II gene polymorphisms as well as the tissue specific regulation of these genes.  We determined that most (> 90%) of the polymorphisms found in the class II genes of the mouse Mhc had survived many speciation events and were most likely due to the steady accumulation of mutations over long evolutionary periods.  This was in stark contrast to pathogen driven hypermutation events proposed by others.  In addition, I characterized the regulatory elements of one of these class II genes, the Ab gene.  An assessment of the chromatin structure revealed a potential enhancer in the second intron.  This was later confirmed via transient transfection assays into B cells.

Honors and Awards:

1993-1996     NRSA: "Mapping the Non-Mhc genes influencing collagen induced arthritis”Awarded by: National Institutes of Arthritis and Musculoskeletal and Skin Diseases,

 1994-1997      NSF:  "Design of a Hands-on Biology course for Elementary Science
                          Teachers".

 1996-1997      CapCURE:  "Genetic mapping of prostate cancer loci in high risk families"
                          Renewed on a yearly basis.

 1996-1997      Darwin Molecular:"Mapping Susceptibility Loci for Rheumatoid Arthritis in a
                          Native American Tribe" Renewed on a yearly basis.

2000-2001             Howard Hughes Medical Institute Biomedical Research Support
 

Study Sections:

2001    ZNS1 SRB-W (01)    NINDS/NIMH Microarray Center & Review Committee

2002    ZAI1-ALR-M-M1     NIAID Unsolicited Program Project Grant

2002    ZDK1-GRB-3 (01)    NIDDK  MTOPS Prostate Samples Analysis Consortium

2002    ZDK1-GRB-2 (C1)   NIDDK BioSample and Genetics Repositories

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