CURRICULUM VITAE
PERSONAL DATA:
Name:
Jin-Xiong She, Ph.D.
Title:
Professor of Pathology and Eminent Scholar in Genomic Medicine;
Director, Center for Biotechnology and Genomic
Medicine;
Vice chair, Department of Pathology;
School of Medicine, Medical College of Georgia
President, Association of Chinese Geneticists in
America
Address:
Center for Biotechnology and Genomic Medicine,
Medical College of Georgia,
1120 15th Street, PV6B108,
Augusta, GA 30912-2400
Phone:
706-823-3973 (O), 706 823-2269 (fax), 706-210-8769 (h)
Email:
jshe@mail.mcg.edu
Birth:
May 24, 1962, Hu-Bei, People's Republic of China
Nationality:
Naturalized USA citizen (No. 24446995) on Feb 29, 2000, Gainesville, FL
Marital status:
Married to Jan Y. She with Son Edward X. She and daughter Amanda R. She
EDUCATION:
Ph.D. (Molecular and Population Genetics), 1984-1987, Univ. of Montpellier II, France
M.S. (Ichthyology),
1983-1984, National School of Agriculture of Toulouse (France)
Graduate Student of Zhong-Shan University, Guang-Zhou (1982-1983)
Training in French, Foreign Language College of Guang-Zhou (1982-1983)
B.S. (Ichthyology),
1978-1982, Agricultural College of Central China (Wu-Han)
ACADEMIC APPOINTMENTS:
2002 -
Professor and Eminent Scholar in Genomic Medicine; Director, Center for Biotechnology and Genomic Medicine; Vice chair, Department of Pathology, Medical College of Georgia
2000- Adjunct Professor, Department of
Genetics, Beijing Union Medical University
Director, NIDDK Biotechnology Center at UF
1997-2002 Director of Research, University of Florida Diabetes Center
1998-2000 Co-Director, Division of Experimental Pathology and Immunology
1999-2000 Adjunct Associate Professor, Department of Pediatrics, University of
Florida
1997-2000 Associate Professor, Department of Pathology, University of Florida
1992-1996 Assistant Director, Molecular HLA typing Laboratory, Dept. of Pathology
1991-1997 Assistant Professor, Department of Pathology, University of Florida
1991-2002 Founding member, Center for Mammalian Genetics, UF
1989-1991 Assistant Research Scientist, Department of Pathology, Univ. of Florida
1988-1989 Postdoc, Dept. of Pathology, UF (Mentor: Edward K. Wakeland, Ph.D.)
HONORS AND AWARDS:
Scholarship, Agricultural College of Central China,
1978-1982
Winner of the Chinese National competition for studying abroad,
1982
Graduate Scholarship, University of Zhong-Shan,
1982-1983
Graduate Scholarship of Chinese and French Governments,
1983-1987
New Faculty Award, Division of Sponsored Research, University of Florida
1992
Research Development Award, Division of Sponsored Research, University of Florida
1992
University of Florida Presidential Outstanding Performance Award
1999
Reviewer for Funding Agencies/Study Sections:
British Diabetes Association
1998-
Distinguished Judge for the 23rd Annual Medical Guild Graduate
The Wellcome Trust
1998-
Italian Telethon
1998
Juvenile Diabetes Foundation/Canadian Medical Research Council
1999
in Autoimmune Disease, NIEHS
1999
Australian Medical Research Council/JDF Centers Review
2000
The Wellcome Trust/JDFI reviewer
2000
The Swiss National Science Foundation
2000
Reviewer for Scientific Journals:
American Journal of Human Genetics,
BioMed Central
Biotechniques
Clinical Endocrinology
Clinical Immunology and Endocrinology
Current Molecular Medicine
Diabetes
Diabetes Care
Diabetes Research and Clinical Practice
Diabetologia
Faculty of 1000
Mammalian Genome
Proceedings of the National Academy of Sciences
Trends in Genetics
Trends in Immunology
PROFESSIONAL MEMBERSHIPS AND POSITIONS:
1995-1997: American Society for Histocompatibility and Immunogenetics
1988-: American Association for Advancement of
Sciences
1993-: American Society of Human Genetics
1993-: American Diabetes Association
1993-: Juvenile Diabetes Foundation
International
1991-: Association of Chinese Geneticists of
America
1999-2003
Board of Directors, Association of Chinese Geneticists of America
2001-2002
President-elect, Association of Chinese Geneticists of America
Steering Committee
INTERNAL COMMITTES:
Center for Mammalian Genetics Steering committee,
1992 - 2002
Department of Pathology Executive Committee,
1998 - 2,000
Center for Mammalian Genetics graduate program committee,
1994 - 1997
Department of Pathology clinical research committee,
1999 - 2002
University of Florida Diabetes Center of Excellence Executive Committee
2000 - 2002
Biomedical Research Council, MCG
2002 -
ACTIVE FUNDING:
NIH, 1U01DK063865 (PI: She)
Title: Consortium for identification of environmental triggers for type 1 diabetes: MCG/UF clinical center
First year direct cost: $570,245
Total direct cost: $3,942,754
This proposal is to identify environmental triggers in a prospectively followed population at high risk for type
1 diabetes.
NIH 5 U24 DK58778-02
(PI: She)
This grant is to establish a biotechnology center for microarray analysis. It involves over 30
investigators from 4 universities.
NIH, 2RO1HD37800-01 (PI: She)
Title: Prospective studies in infants of the immunopathogenesis of type 1 diabetes
Duration: 08/01/99-07/31/07 25% effort
First year direct cost: $540,245
Total direct cost: $2,864,663
This proposal is to evaluate a novel strategy (combining genetic screening of the general population and
monitoring of high risk subjects using autoantibodies and cellular markers) to identify high risk subjects for IDDM.
Project 1 of Program project 2P01 AI-42288-05 (PI: J.X. She)
Title of project 1: B lymphocyte subsets in type 1 diabetes
Duration: 09/1/97-08/31/06 15% effort
Current year direct cost: 140,000
Total: $800,000
This proposal is to study the roles of B cells in the pathogenesis of IDDM in NOD.
Core C of 2P01 AI-42288-05: (PI: She)
Title: Laboratory Core.
Duration: 09/1/97-08/31/06 10% effort
Current year direct cost: 120,000
Total: $600,000
Chinese Science Foundation (399 28020) (PI: JX She)
Linkage studies on Hashimoto's thyroiditis (400,000 yuan, 2000-2004)
KO8 (PI: Chen Liu, Sponsor: Jin-Xiong She)
Role of Liver Cytokines in Hepatitis C viral Infection, 09/02‑‑08/07, Total direct cost:
$595,810
FUNDING PENDING:
PAST FUNDING:
01/01/92 - 12/31/92 Division of Sponsored Research, University of Florida
(PI: JX She), New Faculty Award, Direct Costs: $8,500.00.
05/01/92 - 04/31/94
Division of Sponsored Research, University of Florida (PI: JX She), Faculty development award, Direct Costs: $15,000.00
09/01/93 - 06/30/94 Division of Sponsored Research, University of
Florida (PI: JX She):
Graduate student stipend; Direct Costs: $7,106.00
01/04/93 - 31/04/94
Merck Pharmaceutical (PI: David Rutledge, Co-PI: JX She): Genetics of Hypertension in African Americans; Direct Costs: $20,000.00
01/07/93 - 30/06/95
American Heart Association (PI: David Rutledge; Co-PI: JX She), Association study of ACE gene with hypertension in Blacks, $100,000.
08/01/91 - 06/01/96
National Institute of Health, 1 R01 HL47138 (PI: EK Wakeland, co-PI: JX She):, HLA class II genotyping by DGGE and direct sequencing; Direct Costs: $530,218.
09/01/93 - 04/31/96 Juvenile Diabetes Foundation International,
JDF193182 (PI: JX She):
Title: Sib-pair analysis of insulin-dependent diabetes; Direct Costs: $99,440
05/01/84 - 04/31/97
National Institute of Health, NIH RO1 HD19469-11 (PI: Maclaren, Co-I: JX She): Islet cell autoantibodies and the natural history of IDD, Direct Costs: $2,869,226;
09/01/93 - 08/31/98
National Institute of Health, NIH UO1DK46636-01 (PI: Maclaren, Co-I: JX She):; The effects of oral antigen therapy in IDD; Direct Costs: $6,533,249
09/01/95 - 11/30/97 Juvenile Diabetes Foundation International,
JDF195094 (PI: She):
Genetic and Functional Analysis of HLA Class I Antigen Processing Genes in IDDM;
Direct cost: $100,000
09/01/96 - 02/28/98
Juvenile Diabetes Foundation International, JDF196113 (PI: She):
Confirmation of IDDM susceptibility genes, Total cost: $100,000
06/01/96 - 05/31/98
NIH, 1RO1DK 50220 (PI: She), Title: Affected sibpair and disequilibrium mapping of IDDM genes.. Total direct Costs: $201,515.
08/01/97 - 7/31/99
Juvenile Diabetes Foundation International, JDF197052 (PI: She): (returned to JDF in 1997). Analyses of an IDDM susceptibility gene in the CTLA4/CD28 region, Total cost:
$200,000
08/01/97 - 07/31/00
College of Medicine University of Florida, Program Initiative (PI: She), Title: Genetic screening of high risk subjects to IDDM in newborn babies, total direct cost: $779,500
12/01/98 - 11/31/00
Juvenile Diabetes Foundation International, JDF1-1998-187 (PI: She), Title: Linkage disequilibrium Mapping of IDDM8, Total: $200,000
NIH 1R01 DK53266-01 (PI: She)
Title: Identification and analyses of the urofacial syndrome gene
Duration: 06/01/98-05/31/02 15% effort
Current year direct cost: $152,821
Total direct cost: $801,096
This grant is to identify the Ochoa gene by positional cloning
techniques.
NIH 1R01DK53103 (PI: She)
Title: Genetic and functional analyses of IDDM12 in the CTLA4/CD28 region
Duration: 09/15/97-09/14/01 15% effort
Current year direct cost: $108,000
Total: $418,360
This grant is to identify IDDM12 and perform functional studies.
Sponsor for postdoctoral fellowships:
05/01/99-04/30/00
Juvenile Diabetes Foundation, JDF3-1999-348 (Michele P. Marron, Ph.D.) Title: Genetic and functional analyses of IDDM12, cost: $29,526.
Juvenile Diabetes Foundation, JDF3-1999-671 (Reza Semiromi-Davoodi, Ph.D.)
Title: Fine-mapping and cloning of the IDDM8 gene on chromosome 6q27
07/01/99 - 06/31/2001
Current year cost: $30,720
National Institutes of Health, 1F32 DC00393-01 (Mark A. Eckert, Ph.D.)
Title: Heritability of an anatomical risk factor for dyslexia.
05/01/99 - 04/30/2001
Current year cost: $30,256
Juvenile Diabetes Foundation, JDF10-2001-589 (Reza Semiromi-Davoodi, Ph.D.)
Title: Mutation detection in murine STAT gene family: identification and characterization of a novel point
mutation in DNA binding domain of Stat5b in NOD
07/01/01 - 06/31/20004
Current year cost: $67,331
Total: $205,296
PUBLICATIONS:
1. She, J.X., Autem, M., Kotulas, G.,
Pasteur, N. and Bonhomme, F. Multivariate analysis of genetic exchanges between Solea aegyptiaca and Solea senegalensis (Teleosts, Soleidae). Biol. J. Linn. Soci., 32,
1987,p. 357-371.
2. She, J.X., Guelorget, O., et Autem,
M. Biogeographie: -Presence sympatrique de Solea vulgaris (Quensel, 1806) et Solea aegyptiaca (Chabanaud, 1927) dans le Canal de Suez. C. R. Acad. Sci. Paris, 305(3),
1987, p. 65-68.
3. Goucha, M., She, J.X., Kotulas, G.,
Mathieu, E., Renno, J.F. & Pasteur, N. Solea aegyptiaca et Solea senegalensis: Biosystematique et relations genetiques avec d'autres especes de Soleides de l'Atlantique et de
la Mediterranee. Bioch. System. Ecol. 15(6), 1987, p. 699-708.
4. She, J.X., Bonhomme, F., Boursot,
P., Thaler, L., and Catzeflis, F. Molecular phylogenies in the genus Mus: Comparative analysis of electrophoretic, scnDNA hybridization, and mtDNA RFLP data. Biol.
J. Linn. Soci., 41, 1990, p. 83-103.
5. She, J.X., Boehme, S., Wang, T.W.,
Bonhomme, F. and Wakeland, E.K. The generation of MHC class II gene polymorphism in the genus Mus. Biol. J. Linn. Soc., 41, 1990, p. 141-161.
6. Wakeland, E.K., Boehme, S., and
She, J.X. The generation and maintenance of MHC class II gene polymorphism in rodents. Immunologic Review, 113, 1990, p. 207-226.
7. Wakeland, E.K., Boehme, S., She,
J-X., Tarnuzzer, R.W., Lu, C.C., McIndoe, R.A., Chang, I., and W. Potts. Ancestral polymorphism of MHC class II genes: Divergent alleles advantages, Immunologic
Research, 9, 1990, p. 115-122.
8. She, J.X., Boehme, S., Wang, T.W.,
Bonhomme, F. and Wakeland, E.K. Amplification of major histocompatibility complex class II gene diversity by intra-exonic recombination. PNAS, 88, 1991, p. 453-457.
8. Haga, J.A., She, J.X. and Kao, K.J.
Biochemical Characterization of 39-kDa Class I histocompatibility Antigen in Plasma. J. Biol. Chem. 266(6), 1991, p. 3695-3701.
9. She, J.X. and Wakeland, E.K.
Molecular and genetic mechanisms involved in the generation of Mhc diversity. in J. Klein and D. Klein (eds) Molecular Evolution of the Major Histocompatibility Complex.
Springer-Verlag, Heidelberg. 1991, p. 139-154.
10. Ye, Y. She, J.X., and Wakeland, E.W.
Diversification of class II Aa within the genus Mus. in J. Klein and D. Klein (eds) Molecular Evolution of the Major Histocompatibility Complex. Springer-Verlag,
Heidelberg. 1991, p. 131-139.
11. Ferl, R.J.; Nairn, C.J., She, J-X., Wakeland,
E.K., Almira, E. The application of automated DNA sequence Analysis to Phylogenetic Studies in Phylogenetic analysis of DNA sequences, Oxford Press. M. Miyamoto and J.
Cracraft, eds., 1991, p. 45-58.
12. Hermel, E., Ribinson, P.J. She, J.X., and
Fisher Lindahl, K. Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection. Immunogenetics 38, 1993
p. 106-116.
13. Lamers, S.A., Leasman, J.W., She, J.X.,
Barrie, K.A., Pomeroy, S.M., Barrett, D.J. and Goodenow, M.M. Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of
human immunodeficiency virus type 1 in vivo. J. Virology, 67(7), 1993, p. 3951-3960.
14. She, J.X., Zhang, L.P., J. Scornik and
Wakeland, E.K. A novel HLA DR allele: DRB1*0810. Immunogenetics 39 (1), 1994, p. 78.
15. Chesnut, K., She, J.X., Cheng, I.,
Muralidharan, K. and Wakeland, E.K. Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain. Mammalian Genome, 4, 1993, p.549-554.
16. Maclaren, N., Muir, A., Silverstein,J.,
Song,Y.H., She, J.X., Krischer,J., Atkinson,M. and Schatz,D. Early diagnosis and specific treatment of insulin-dependent diabetes. in Immunosuppressive and antiinflammatory drugs,
eds. Allison,A.C., Lafferty,K.J. and Fliri,H. The New York Academy of Sciences, New York, 1993, pp. 343-350.
17. Lamers, S.A., Leasman, J.W., She, J.X.,
Kimberly, A., Barrie, K.A., Pomeroy, S.M., Barrett, D.J. and Goodenow, M.M. Persistence of multiple maternal genotypes of human immuno-deficiency virus type I in infants
infected by vertical transmission. J. Clin. Invest. 93, 1994, p. 380-390.
18. Song, Y.H., Connor, E.L., Muir, A., She, J.X.,
Zorovich, B., Brooks, D. and Maclaren, N.K. Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison disease. J. Clin. Endo. Metab. 78(5), 1994, pp.
1108-1112.
19. She, J.X., Bui, M.M., Tian, X.H., Muir, A.,
Wakeland, E.K., Zorovich, B., Zhang, L.P., Liu, M.C., Thomson, G. and Maclaren, N.K., Additive Susceptibility to Insulin-Dependent Diabetes Mellitus Conferred by HLA-DQB1 and Insulin
Genes. Autoimmunity, 1994, 18:195-203.
20. Huang, W., She, J.X., Muir, A., Laskowska,
Zorovich,B., Schatz,D. and Maclaren, N.K. High Risk HLA-DR/DQ Genotypes for IDD Confer Susceptibility for to Autoantibodies but DQB1*0602 does not Prevent them. J. Autoimmunity,
1994, 7:889-897.
21. Song, Y.H., Connor, E.L., She, J.X., Muir, A.,
Zorovich, B. and Maclaren, N.K. Addison's disease and the type II autoimmune polyglandular syndrome: the 21-hydroxylase autoantigen, in Advances in Thomas Addison's Diseases
eds. Bhatt, James, Besser, Boottazzo & Keen, vol 1, pp 115-122. 1994, J. Endocrinol. Limited, Bristol, UK.
22. Deng, Y.G., Muir, A., Maclaren, N.K., and She,
J.X. Association of LMP2 and LMP7 in the major histocompatibility complex with insulin-dependent diabetes mellitus: Population and family studies. Am. J. Hum.
Genet. 1995, 56:528-534.
23. Luo,D.F., Bui, M, Muir, A., Maclaren, N.K.,
Thomson, G., and She, J.X., Affected sibpair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27. Am. J. Hum.
Genet. 1995, 57:911-919.
24. Huang HS, JT Peng, JY She, LP Zhang and JX
She, HLA-encoded susceptibility to IDDM is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population, Human Immunology, 1995, 44:210-219.
25.
Luo DF, Maclaren NK, Huang HS, Muir A, and She JX, Intrafamilial and Case-control association analysis of D2S152 in insulin-dependent diabetes. Autoimmunity
1995, 21(2):143-147.
26. Zhang, L.P. and She,J.X. Denaturing gradient
gel electrophoresis. in Yongming Li and Yuqi Zhao (eds), Practical Protocols in Molecular Biology. 1995, 10-13.
27. She,J.X. Rapid clone screening using
polymerase chain reaction. in Yongming Li and Yuqi Zhao (eds), Practical Protocols in Molecular Biology. 1995, 35.
28. Bui, M.M. and She,J.X. Analysis of
microsatellite polymorphisms using the polymerase chain reaction. in Yongming Li and Yuqi Zhao (eds), Practical Protocols in Molecular Biology. 1995, 142-144.
29. Bui, M. M., Luo, D.F., She, J.Y., Muir, A.,
Thomson, G., Maclaren, N.K. and She, J.X., Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas.
J. Autoimmunity, 1996, 9:97-103.
30. Lu, C.C., Ye.Y., She, J.X., Bonhomme,F. and
Wakeland, E.K., Evolutionary origins of retroposon lineages of Mhc class II Ab alleles, Immunogenetics, 1996, 43(3):115-124.
31. Deng, Y.G., Huang, H.S., Zhang, L.P., Maclaren,
N.K., and She, J.X. Polymorphism and linkage disequilibrium of TNFa: No primary association with IDDM. Human Immunology, 1996, 45:137-142.
32. Luo D.F., Buzzetti,R., Rotter,J., Maclaren,N.K.,
Raffael,L., Nistico,L., Giovannini,C., Pozzilli,P., Thomson,G. and She,J.X. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5
and IDDM8. Human Molecular Genetics, 1996, 5(5):693-698.
33. She, J.X. Susceptibility to type I
diabetes: HLA-DQ and -DR revisited. Immunology Today, 1996, 17(7):323-329.
34. Huang, W., Connor,E., Delarosa,T., Muir,A.
Schatz,D., Silverstein,J. Crockett,S., She,J.X. and Maclaren, N.K. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular
syndromes, the human leucocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta cell autoimmunity. J. Clin. Endocrinol. Metab. 1996, 81(7):1-5.
35. Bhisitkul,D.M., Vinik,A.I.,
Morrow,A.L., She,J.X., Shults,J., Powers,A.C., Maclaren,N.K. Prediabetic markers in children with stress hyperglycemia. J.Pediatrics, 1996, 135, 936-939.
36. Wang, CY., Hawkins-Lee, B., Ochoa,B.,
and She,J.X. 1997. Homozygosity mapping of the Ochoa (Urofacial) Sndrome Gene to 1 cM region on chromosome 10q23-q24. Am. J. Hum. Genet. 60:1461-1467.
37. Marron, M., L.J. Raffel, H.J. Garchon,
C. O. Jacob, M.T. Martinez Larrad, W.-P. Teng, Y.S. Park, Z.-X. Zhang, D.R. Goldstein, Y.-W. Tao, G. Beaurain, M. S. Rios, J.-F. Bach, H.-S. Huang, D.F. Luo, A. Zeidler, J.I.
Rotter, M.C.K. Yang, N. K. Maclaren and J.X. She, Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum.
Mol. Genet. 1997, 8:1275-1282.
38. Lernmark, A., Eisenbarth,G., Ducat,L.,
Erlich,H.A., Faustman,D., Maclaren,N.K., Ott,J., Permutt,A., She, J.X., and Todd,J.A. 1997, Family cell lines available for research - an endengered resource? Am.
J. Hum. Genet. 61 (3): 778-779.
39. Ellis, T.M., Schatz,D., Ottendorfer,E.W.,
Lan,M.S., Wasserfall,C., Salisbury,P.J., She,J.X., Notkins,A.L., Maclaren,N.K. and Atkinson,M.A. 1998, The relationship between humoral and cellular immunity to IA-2 in IDDM,
Diabetes, 47:566-569.
40. Ellis, T.M., Ottendorfer, E., Jodoin, E.,
Salisbury, P.J., She, J.X., Schatz, D.A., Atkinson, M.A. 1998, Cellular immune responses to b casein: elevated in but not specific for individuals with Type I diabetes mellitus,
Diabetologia, 41: 731-735.
41. Park, Y.S., Wang, C.Y., and She,.J.X., 1998.
HLA-DR and DQ contribute to suscetibiloty to insulin-dependent diabetes mellitus (IDDM) in Koreans. Hum. Immunol., 59, 794-801.
42. Ahmed,S., Ayoub,E.M., Scornik,J.C., Wang,C.Y.
and She,J.X. 1998, Poststreptococcal reactive arthritis: clinical characteristics and association with HLA-DR alleles. Arthritis & Rheumatism, 41(6):1096-1102.
43. She, J.X. and Marron, M.P. 1998, Genetic
Susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses, Curr. Opin. Immunol., 10:682-689.
44. Chen, Q.Y., Lan, M.S., She, J.X. and Maclaren,
N.K.. 1998, The gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in US patients, J Autoimmun, 11(2):177-183.
45. She, J.X. Genetic Factors in Type I Diabetes:
A Complex Disease. J. Clin. Ligand Assay, 1998, 21:272-281.
46. Wang CY, Davoodi-Semiromi,A., W. Huang, E. Connor,
Jing-Da Shi and J.X. She, 1998, Characterization of mutations in autoimmune polyglandular syndrome type 1 (APS1) patients, Hum.Genet. 103:681-685.
47. Wang CY, JD Shi, A Davoodi-Semiromi and JX
She, 1999, Cloning of Aire, the mouse homologue of Autoimmune Regulator (AIRE) Gene Responsible for Autoimmune Polyglandular Syndrome Type 1 (APS1), Genomics,
55:322-326.
48. Ellis TM, Jodoin E, Ottendorfer EW, Salisbury
PJ, She JX, Schatz D, and Atkinson MA 1999, Cellular immune responses against proinsulin: No evidence for enhanced reactivity in individuals with IDDM, Diabetes, 48:299-303.
49. Muir A, Ruan QG, Marron MP and She JX 1999,
The IDDMK1,222 Retrovirus is not detectable in either mRNA or genomic DNA from patients with type 1 diabetes, Rapid publication, Diabetes, 48:219-222.
50. Maclaren,N. Lan,M. Coutant,R.
Schatz,D. Silverstein,J. Muir,A. Clare-Salzler M. She,JX, Malone,J. Crockett,S. Schwartz,S. Quattrin,T. DeSilva,M. Vander Vegt,P. Notkins,A. and Krischer,J. Only multiple
autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2 beta predict immune-mediated (type 1) diabetes in relatives. J. Autoimmun. 1999 12 (4):279-287.
51. She, J.X., Tamir M. Ellis, S. Brian Wilson,
Clive H. Wasserfall, Michele Marron, Sharon Reimsnider, Sally C. Kent, David A. Hafler, Donna S. Neuberg, Andy Muir, Jack L. Strominger and Mark A. Atkinson. Heterophile
antibodies segregate in families and are associated with protection from Type 1 diabetes. Proc. Natl. Acad. Sci. USA, 1999, 96 (14), 8116-8119.
52. Wang, C.Y., Huang, Y.Q., Shi, J.D., Marron,
M.P., Ruan,Q.G., Hawkins-Lee,B., Bernardo Ochoa2 and Jin-Xiong She1
(1999), Genetic Homogeneity,
High-Resolution Mapping and Mutation Analysis of the Urofacial (Ochoa) Syndrome, Am.J.Med.Genet 84:454-459.
53. Litherland SA, Xie XT, Hutson AD, Wasserfall
C, Whittaker DS, She J, Hofig A, Dennis MA, Fuller K, Cook R, Schatz D, Moldawer LL, Clare-Salzler MJ, Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell
defect for insulin-dependent diabetes mellitus. J. Clin. Invest. 104(4):515-523.
54. Shi JD, Wang CY, Marron MP, Huang YQ, Detter
JC, Davoodi-Semiromi A and She JX, Complete genomic sequence, gene structure and localization of the mouse Aire gene, Autoimmunity, 1999, 31:47-53.
55. Ruan QG, Wang CY, Shi JD and She JX,
Expression and alternative splicing of the mouse Aire gene, J. Autoimmunity, 1999 13:307-313.
56. Wang CY, Shi JD, Ochoa B, Hawkins-Lee B, Huang
YQ and She JX, Construction of a physical map for a 1-Mb genomic region containing the urofacial (Ochoa) syndrome gene on 10q23-q24. Genomics. 60:12-19.
57. She JX, Genetic factors in diabetes mellitus,
in Clinical diabetes mellitus: A problem-oriented approach. 3rd edition, ed: J.K. Davidson, 2000, 69-85.
58. Muir A and She JX, 1999, Advances in the
genetics and immunology of autoimmune polyglandular syndrome II/III and their clinical applications, Ann. Med. Interne., 150 (4):301-312.
59. Chen QY, Huang W, She J.X., Baxter F,
Volpe R, Maclaren NK. 1999, HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is
protective. J Clin Endocrinol Metab 84(9):3182-6
60. Marron MP, Hopkins D, Eckenrode,S. Park,Y.S.
and She,J.X. 1999, NeuroD/Beta2 Polymorphism is not Associated with Type 1 Diabetes in Chinese, Korean, or Caucasian Populations, Endocrine Genetics. 1:73-77.
61. Marron MP, Zeidler A, Raffel LJ, Garchon HJ,
Jacob CO, Serrano-Rios M, Larrad MTM, Park YS, Bach JF, Rotter JI, Yang MCK, She JX, Genetic and physical fine-mapping of a Type 1 diabetes susceptibility gene (IDDM12) near
CTLA4 on chromosome 2q33. Diabetes. 2000, 49:492-499.
62. Eckenrode S, Reimsnider S, Marron MP and She
JX, Fine-mapping and candidate gene analysis of a type 1 diabetes susceptibility gene on chromosome 11q23 (IDDM4). Hum. Genet. 2000, 106 (1): 14-18.
63. Reimsnider S, Leung E,
Marron MP, Wang CY and She JX, No evidence for association between type 1 diabetes and IL4 or IL4 receptor a
genes, Pediatric Research 2000 Feb;47(2):246-9.
64.
Wasserfall C, Atkinson M, Jodoin E, Schatz D, She JX, Henderson LO and Ellis, T. Glutamic Acid Decarboxylase and IA-2 Autoantibodies in Type 1 Diabetes: Comparing Sample
Substrates for Autoantibody Determinations. Pediatric Diabetes, 2000, 1:10-16.
65.
She JX, Eckenrode S, Ruan QG, Marron MP, Li QZ, Mark C.K. Yang, J Yang, D Hopkins, A Muir and RA McIndoe, Microarray Technology
in the Pathogenesis and Management of Autoimmune Disorders, 2000 the Ernst Schering Research Foundation Workshop supplement 7 pp1-14.
66.
Park YS, She JX, Wang CY, Erlich H, Noble JA, Eisenbarth GS, Common susceptibility and transmission pattern of HLA DRB1-DQB1
haplotypes to Korean and Caucasian patients with type 1 diabetes. JCEM, 2000, 85(12):4538-4542.
67.
Bartoloni L, Blouin JL, Maiti A, Sainsbury A, Rossier C, Gehrig C, She, JX, Marron MP, Lander E, Meeks M, Chung E, Armengot M,
Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE, Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure and investigation of its role in
primary ciliary Dyskinesia. Genomics 2001, 72:21-33.
68.
Guttmann-Bauman I, Shi JD, Wang CY and She JX, Detection of AIRE mutation in an atypical autoimmune polyglandular
syndrome type 1 (APS1) patient. J. Pedeiatrics (In press)
69.
Shi JD, T Kukar, CY Wang, QZ Li, PE Cruz, A Davoodi-Semiromi, P Yang, YR Gu, W Lian, DH Wu and JX She, Molecular
Cloning and Characterization of A Novel Mammalian Endo-Apyrase (LALP1) JBC, 2001:276(20):17474-17478.
70.
Park, Y.S., She, J.X., Noble, J.A., Erlich, H., Rewers,M., Eisenbarth,G.S. Transracial evidence for the influence of the
homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children. Tissue Antigens, 2001, 57(3):185-191.
71.
Morales AE, She JX and schatz DA, 2001, Prediction and prevention of type 1 diabetes, Current Science, (in press).
72.
Cai T, Xie JP, She JX and Notkins AL, Analysis of the coding and promoter regions of the insulin-dependent diabetes mellitus
associated autoantigen IA-2 in subjects with IA-2 autoantibodies. Diabetes, 2001:50:2406-2409.
73.
Li QZ, Eckenrode S, Ruan QG, Wang CY, Shi JD, McIndoe RA, She JX: Rapid decrease of RNA level of a novel mouse
mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. Mamm Genome. 2001 Nov;12(11):830-6
74.
Kumar, P. G., Laloraya, M., Wang, C. Y., Ruan, Q. G., Davoodi-Semiromi, A., Kao, K. J., and She, J. X. (2001). The
Autoimmune Regulator (AIRE) Is a DNA-binding Protein. J Biol Chem 276:41357-41364.
75.
Yang, M. C., Ruan, Q. G., Yang, J. J., Eckenrode, S., Wu, S., McIndoe, R. A., and She, J. X. (2001). A statistical method
for flagging weak spots improves normalization and ratio estimates in microarrays. Physiol Genomics 7:45-53.
76.
Li QZ, Wang CY, Shi JD, Ruan QG, Eckenrode S, Davoodi-Semiromi A, Kukar T, Gu Y, Lian W, Wu D, She JX. Molecular cloning
and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Gene. 2001 Aug 8;273(2):275-84.
77.
Schatz DA, Krischer J, She J-X. To Screen or not to Screen for pre-Type 1 Diabetes? Hormone Research 2002; 57 (suppl
1): 12-17.
78.
Kumar PG, Laloraya M, She JX. Population genetics and functions of the
autoimmune regulator (AIRE). Endocrinol Metab Clin North Am 2002, 31(2):321-38.
79.
Davoodi-Semiromi A, Yang JJ, She JX. IL-12p40 is associated with type 1 diabetes in Caucasian-American families.
Diabetes. 2002, 51(7):2334-6.
80.
Kukar T, Eckenrode S, Gu Y, Lian W, Megginson M, She JX, Wu D., Protein microarrays to detect protein-protein
interactions using red and green fluorescent proteins. Anal Biochem. 2002 Jul 1;306(1):50-4.
81.
Casp CB, She JX, McCormack WT, Genetic association of the Catalase gene (CAT) with vitiligo susceptibility.
Pigment Cell Research, 2002, 15: 62-66.
82.
Li SW, Tang D, Ahrens KP, She JX, Braylan RC, Yang L. All-trans retinoic acid induces CD52 expression in acute promyelocytic leukemia. Blood. 2002, Oct 17
83.
Wang CY, Abodoreza Davoodi-Semiromi, Jing-Da Shi, Ping Yang, Yi-Qun Huang, Jose A. G. Agundez, Jose M. Moran, Bernardo
Ochoa, Bobbilynn Hawkins-Lee and Jin-Xiong She: High resolution mapping and mutation analyses of candidate genes in the urofacial syndrome (UFS) critical region, AJMG 2002 (in press)
84.
Yang LJ, Zhao HS, Li SW, Collins C, Douglas V, Braylan RC, Eckenrode S, Ruan QG, Mcindoe R and She JX: Gene expression
profiling of all-trans retinoic acid-induced cell differentiation in acute promyelocytic leukemia. Submitted to Blood. In press
85.
Wang CY, Jing-Da Shi, Ping Yang, Pradeep G. Kumar, Quan-Zhen Li, Qing-Guo Run, Yun-Chao Su, Hamish S. Scott, Kuo-Jang Kao
and Jin-Xiong She, Molecular Cloning and Characterization of a Novel Gene Family of Four Ancient Conserved Domain Proteins (ACDP). Gene, 2002 (in press).
86.
Semiromi-Davoodi R, Laloraya M, Kumar, GP and She JX. A mutant Stat5b with weaker DNA binding affinity
defines a key defective pathway in non-obese diabetic (NOD) mice, Nature Genetics (in review).
87.
Eckenrode S, QG Ruan, QZ Li, P Yang, Zhao HS, Collins C, MCK Yang, J Yang, D Hopkins, A Muir, MP Marron, R McIndoe and JX She,
Global gene expression analysis by microarray identified a rapid increase of B cell population during the onset of insulitis in NOD mice (in preparation).
88.
Qing-Guo Ruan, Sarah Eckenrode, Quan-Zhen Li, Ping Yang, Mark C.K. Yang, James Yang, Andy Muir, Richard McIndoe and Jin-Xiong
She, Global gene expression changes induced by Cyclophosphamide treatment and insulin immunization (In preparation).
89.
Yang M, Yang J, McIndoe R and She JX, Statistical analysis of microarray data: sample size and power calculation.
Submitted to Physiological Genomics
90.
Yang J, Yang M, McIndoe R and She JX, Statistical analysis of microarray data: Multiple non-parametric permutation test (MNPA).
91.
Tang, L and She JX: A neural network model for microarray data analysis (in preparation).
92.
Wilson K, Croker B, Eckenrode S, Ruan QG, Mcindoe R and She JX: Differentially expressed genes between diabetic and
normal NOD mice.
93.
Collins C, Zhao HS, Rewers M, Hopkins D, North K, Schatz D, Muir A, Atkinson M, Eckenrode S, Ruan QG, Mcindoe R and She
JX: Predictive markers for type 1 diabetes and associated autoantibodies in a prospective cohort by microarray analysis (in preparation).
94.
,
Shawn Levy, Alfred L. George, Jr., Michael J. Lombardi, Steven R. Gullans, Juergen Naggert, Sarah Eckenrode, Jin-Xiong She,
Stephen C. Dahl, Qingbin M. Guo, Lisa D. White, Robert C. Thompson, Kei-Hoi Cheung, Robert A. Star,
PATENTS:
US Patent Application S/No. 10/199,229: Activators of cyclin-dependent kinases
INVITED PRESENTATIONS:
1992
Department of Medicine, Division of Oncology, University of Florida, Sept. 1992. Molecular typing of the HLA
using DGGE and direct sequencing.
1993
Academy of Chinese Medical Sciences (Beijing, China): Modern Molecular Biology Techniques.
1993
Association of Chinese Students and Scholars at UF (July): Recent progresses in human genetics.
1993
Association of Chinese Students and Scholars at UF (Nov.): The human genome project: Methods and progresses.
1993 Center for
Mammalian Genetics: Recent progress of linkage and association analysis of IDD.
1993 Hunan Medical
University, China. (Jan.): Linkage analysis of insulin-dependent diabetes.
1993 Hunan Medical
University, China: Molecular methods for HLA Class II genotyping.
1993 Beijing
Medical University, China (Feb.): Linkage analysis of insulin-dependent diabetes.
1993
Academy of Medical Sciences, China, (Feb.): The human genome project and human population genetics.
1993 12th
International Immunology and Diabetes Workshop (April, Orlando): Association and Linkage Analyses of Insulin-dependant Diabetes
1994
American Diabetes Association Annual Meeting (New Orleans, June)
1994 Pig Institut
of Taiwan (July): Molecular evolution of MHC genes and application of DGGE.
1994 Taiwan
National University, Department of vetenary Medicine (July): Recent advance of molecular techniques.
1994
Changgun Memorial Hospital (July): HLA typing by allele-specific amplification, DGGE and sequencing.
1994 UF Department
of Medicine, Division of Rheumatology: Pedigree analyses of complex traits.
1995
16th International Diabetes workshop (Italy): Genetic mapping of type 1 diabetes genes.
1996
American Diabetes Association (Denver): Genetic screening of diabetes in the general population
1996 American Society of human
genetics (San Francisco, Nov.): TAP and LMP genes in type 1 diabetes.
1997
International Workshops (NIH and JDF): Genetics of type 1 diabetes.
1997 Millennium
Pharmaceuticals: Genetic dissection of monogenic and complex diseases.
1997 Molecular Darwin (Seattle,
Feb.): Genetics and immunology of autoimmune polyglandular syndromes.
1997 Bristol-Myers Squib (Seattle, Feb.):
CTLA4 and type 1 diabetes.
1997 UF Department of Medicine, Division of
Rheumatology: Genetic analyses of complex traits.
1997 George Washington University Children's
Hospital: Genetic dissection of monogenic and complex traits.
1998
American College of Medical Genetics Annual Congress: Non-HLA genes of insulin-dependent diabetes.
1998 Babara Davies Center for Childhood
Diabetes, University of Colorado: Type 1 diabetes: genetics and immunology
1998
International Congress of Genetics (Beijing China): Genetics of complex diseases: type 1 diabetes
1999
Human Biological Data Interchange Steering Committee (Chicago): Familial Autoimmunity and genome amplification.
1999 CDC Workshop on dried blood spots in
diabetes prevention research (Atlanta, March).
1999 2nd International Congress on
Autoimmunity (Telaviv, Israel, March): APS1: Monogenic autoimmunity of AIRE.
1999
Children's Hospital of Philadelphia and University of Pennsylvania: Genetic susceptibility and immunopathogenesis of type 1 diabetes.
1999
University of Louisville: Genetics and screening of type 1 diabetes.
1999 The 8th International symposium
of Society of Chinese Bioscientists in America (SCBA) (Hong Kong, July): Molecular genetics of diabetes.
1999 Beijing Union Mecial University (July),
Novel approaches for the studies of complex diseases.
1999 Plenary lecture: The 3rd
International Diabetes Society Congress (Italy, November), Global gene expression analysis in type 1 diabetes using cDNA microarray.
1999
Opening lecture for "New Concepts in Pathology and Treatment of Autoimmune Disorders" (Schering AG Symposium, Berlin, December 2/3,), Microarray technology in the pathogenesis and
management of autoimmune disorders.
1999 Invited seminar at University of Texas at
Houston (December 15): Genetic dissection of type 1 diabetes genes by linkage and microarray analyses.
2000
Invited speaker: Workshop on future directions in prevention of type 1 diabetes (January 9-10, 2000, Miami, FL), Functional
genomics.
2000 Invited seminar at University of Minnesota
(March 8): Genetic analyses of type 1 diabetes genes using linkage mapping and microarray analyses.
2000
Invited seminar at University of Florida Department of Medicine (March): Microarray technology in biomedical research.
2000 Invited seminar at The Robarts Research
Institute University of Western Ontario (May 31): Prediction of type 1 diabetes by genetic polymorphisms and microarray analysis.
2000
Invited speaker at the workshop on New Directions in Fluorescence Intensity Standards (NIST, Gaithersburg MD) (June 1-2): Clinical application of microarray.
2000
Guest Speaker at BioRad Workshop “Discover what’s new in Gene Expression: from genomes to proteomes”, Applications of Real-Time PCR in Risk Prediction for Complex Diseases,
July 25, 2000, Raleigh-Durham.
2000
Guest Speaker at BioRad Workshop “Discover what’s new in Gene Expression: from genomes to proteomes”, Applications of Real-Time PCR in Risk Prediction for Complex Diseases,
July 27, 2000, Atlanta
2001 Microarray analysis for gene expression:
challenges and opportunities, Cancer Biology Seminar, University of Florida. Feb 23, 2001
2001
Global gene expression analyses by microarray: opportunities and challenges, University of Turku, Finland.
2001
Recent advances in genetics of type 1 diabetes, University of Turku, Findland.
2001 Microarray technology and public health. Shanghai
Center for Disease Control, Shanghai.
2001
Genetic analyses of human diseases, Beijing University, Beijing.
2001/10 The genomic revolution and paradigm shift in medicine,
Medical College of Georgia
2001/10 Update on the PANDA program, Workshop on Etiology and
epidemiology of early autoimmune type 1 diabetes in humans (NIDDK), Alexandria, VA
2001/10 Application of genomics and proteomics to
pathogenesis, Workshop on Etiology and epidemiology of early autoimmune type 1 diabetes in humans (NIDDK), Alexandria, VA
2002/3 Prediction of type 1 diabetes by microarray and
proteomics tools, California Department of Health, Oakland, California
2002/10 13th Immunology of Diabetes Society Meeting
Faculty: Genomics of Type 1 Diabetes, Denver.
2002/10: Workshop: Applying Bioinformatics: From Genes to
Systems. Functional Genomics of Type 1 diabetes. Georgia State University.
2002/10 The 6th Carousel of Hope workshop, Prediction of
type 1 diabetes using gene expression tools. Hollywood, California.
2002/11 Department of Cell Biology, MCG: Genomic research
tools.
2002/11 Department of Pathology: Genomics and Modern
Pathology.
2002/12 Shanghai Center for Disease Control and Prevention:
New trends in proteomic research.
TRAINEES:
Graduate students:
Marilyn M. Bui, Ph.D. (1991-1996): Faculty at University Hospital (UF) in Jacksonville
Michele P. Marron, Ph.D. ( 1995-1999): Postdoc at Jackson Laboratory
Sharon Reimsnider (1997 - 1999)
Sarah Eckenrode (1998 - 2002)
James Yang (1998 - 2002)
Christin Collins (2000 - )
Qing-Guo Ruan (1998 - )
Daniel Eiseman (2001 -)
Postdoctoral Fellows:
Bobbylin Hawkins-Lee, MD (1995-1996): United States Army
Ya-Guang Deng, Ph.D. (1994-1995): Stanford University
Cong-Yi Wang, MD (1996-1998): Assistant Professor, Medical College of Georgia
Jing-Da Shi, Ph.D. (1997 - 2001): Senior Biological Scientist, Director, UF sequencing facility.
Reza Davoodi-Semiromi, Ph.D. (1997 - 2002): University of Florida
Ed Leung, Ph.D. (1998-1999): Postdoc at Ohio University.
Quan-Zhen Li, Ph.D. (1999 - 2001): Assistant Research Scientisit, Univ. Texas Southwest
Michele P. Marron, Ph.D. (1999 - 2,000): postdoc at Jackson Laboratory
Mark A. Eckert, Ph.D. (1999 - 2001): Instructor, University of Florida Brain Institute.
Honshan Zhao, Ph.D. (1999 - 2002): Scientist, Beijing Medical University
Pradeep Kumar, Ph.D. (2,000 - 2002): Associate Professor, India
Malini Laloraya, Ph.D. (2,000 - 2002): Assistant Professor, India
Karen Wilson, Ph.D. (2,000 - present)
Dhiraj Chhaparwal, MD (2,001 - 2002): University of Florida
Alba Luba, MD (2,000 – 2002): University of Florida
Sharad Purohit (2001 - )
Weiping Zheng, MD (2001 - )
Sarah Eckenrode, Ph.D. (2002 -)
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